Isolation of MERS Coronavirus from a Dromedary Camel, Qatar, 2014
نویسندگان
چکیده
We obtained the full genome of Middle East respiratory syndrome coronavirus (MERS-CoV) from a camel in Qatar. This virus is highly similar to the human England/Qatar 1 virus isolated in 2012. The MERS-CoV from the camel efficiently replicated in human cells, providing further evidence for the zoonotic potential of MERS-CoV from camels.
منابع مشابه
Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels, Oman, 2013.
A countrywide survey in Oman revealed Middle Eastrespiratory syndrome coronavirus (MERS-CoV) nucleicacid in five of 76 dromedary camels. Camel-derivedMERS-CoV sequences (3,754 nucleotides assembled from partial sequences of the open reading frame (ORF)1a, spike, and ORF4b genes) from Oman and Qatar were slightly different from each other, but closely related to human MERS-CoV sequences from the...
متن کاملAuthors reply: Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels: are dromedary camels a reservoir for MERS-CoV?
In fact, we mentioned in our paper [2] in detail that the cycle threshold (Ct) values in nasal and conjunctival swabs of the five MERS-CoV reverse transcriptionquantitative polymerase chain reaction (RT-qPCR) positive Omani camels ranged from as low as 15.74 to 36.29, indicating a high viral load in the former. Our results were confirmed in a recent report by Raj et al. [3], who demonstrated an...
متن کاملEvidence for camel-to-human transmission of MERS coronavirus.
We describe the isolation and sequencing of Middle East respiratory syndrome coronavirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirmed MERS-CoV infection after close contact with camels that had rhinorrhea. Nasal swabs collected from the patient and from one of his nine camels were positive for MERS-CoV RNA. In addition, MERS-CoV was isolated fro...
متن کاملReplication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels
In 2012, a novel coronavirus associated with severe respiratory disease in humans emerged in the Middle East. Epidemiologic investigations identified dromedary camels as the likely source of zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV). Here we provide experimental support for camels as a reservoir for MERS-CoV. We inoculated 3 adult camels with a human isola...
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We identified the near-full-genome sequence (29,908 nt, >99%) of Middle East respiratory syndrome coronavirus (MERS-CoV) from a nasal swab specimen from a dromedary camel in Egypt. We found that viruses genetically very similar to human MERS-CoV are infecting dromedaries beyond the Arabian Peninsula, where human MERS-CoV infections have not yet been detected.
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